2003 William B. Kirlin
Research Award Recipient
Robert H. Cox, Ph.D. - Lankenau Institute for Medical Research
“Statins Inhibit Peroxynitrite Mediated Vascular Dysfunction”
Paul Joseph DiMuzio,
Sr., M.D. -
“A Novel Tissue-Engineerede
Vascular Conduit: Seeding of Decellularized Venous
Allograft With Autologous Mesenchymal Stem Cell”
2003 Millennium
Pharmaceutical Research Award Recipient
Gurusher Panjrath, MBBS - Drexel University College of Medicine
“Effect of Doxorubicin on Serum Lipid Levels in
Humans”
My research involves
understanding the mechanism of Doxorubicin induced cardiomyopathy.
Doxorubicin, a commonly used drug to treat cancer, causes heart failure. The
underlying mechanism of cardiac damage is still not clear. We are trying to
understand the various effects of this drug on physiologic processes and their
relationship to cardiotoxicity. This grant from the
Cardiovascular Institute of Philadelphia will help us focus on metabolic
abnormalities and their role in cardiac damage in patients undergoing therapy
with Doxorubicin. Research from this generous support has provided me with an
opportunity to pursue this important study and help me understand an important
mechanism which may prevent cardiac damage in a significant population of
cancer patients.